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Antioxidants, Free Full-Text

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Antioxidants, Free Full-Text

A limited number of antifungal drugs, the side-effect of clinical drugs and the emergence of resistance create an urgent need for new antifungal treatment agents. High-throughput drug screening and in-depth drug action mechanism analyzation are needed to address this problem. In this study, we identified that artemisinin and its derivatives possessed antifungal activity through a high-throughput screening of the FDA-approved drug library. Subsequently, drug-resistant strains construction, a molecular dynamics simulation and a transcription level analysis were used to investigate artemisinin’s action mechanism in Candida glabrata. Transcription factor pleiotropic drug resistance 1 (PDR1) was an important determinant of artemisinin’s sensitivity by regulating the drug efflux pump and ergosterol biosynthesis pathway, leading to mitochondrial dysfunction. This dysfunction was shown by a depolarization of the mitochondrial membrane potential, an enhancement of the mitochondrial membrane viscosity and an upregulation of the intracellular ROS level in fungi. The discovery shed new light on the development of antifungal agents and understanding artemisinin’s action mechanism.

Mitochondria Circadian Rhythm Flash Sales

Mitochondria Circadian Rhythm Flash Sales

Nitric Oxide Dioxygenase Activity of a Nitrosyl Complex of  Mn(II)-Porphyrinate in the Presence of Superoxide: Formation of a  Mn(IV)-oxo Species through a Putative Peroxynitrite Intermediate, onoo 2 no2

Nitric Oxide Dioxygenase Activity of a Nitrosyl Complex of Mn(II)-Porphyrinate in the Presence of Superoxide: Formation of a Mn(IV)-oxo Species through a Putative Peroxynitrite Intermediate, onoo 2 no2

Antioxidants, Free Full-Text

Antioxidants, Free Full-Text

Antioxidants, Free Full-Text

Antioxidants, Free Full-Text

Antioxidants, Free Full-Text

Antioxidants, Free Full-Text

MitoQ and Reduced Glutathione Protects Against Dopamine Induced Brain  Mitochondrial Electron Transport Chain Inhibition During Extended In Vitro  Incubation: Involvement of Free Radicals and Quinone Products - MDS  Abstracts, onoo 2

MitoQ and Reduced Glutathione Protects Against Dopamine Induced Brain Mitochondrial Electron Transport Chain Inhibition During Extended In Vitro Incubation: Involvement of Free Radicals and Quinone Products - MDS Abstracts, onoo 2

Antioxidants, Free Full-Text, draw it to know it

Antioxidants, Free Full-Text, draw it to know it

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Antioxidants, Free Full-Text, giro gratis coin master levvvel

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Antioxidants, Free Full-Text, renato ruiz pacheco

Antioxidants Free Full-Text Crustacean Waste-Derived, 50% OFF

Antioxidants Free Full-Text Crustacean Waste-Derived, 50% OFF

Antioxidants, Free Full-Text, giro gratis coin master levvvel

Antioxidants, Free Full-Text, giro gratis coin master levvvel